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Chemical Structure : BI-907828
Catalog No.: PC-20668Not For Human Use, Lab Use Only.
BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53.
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BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53.
BI-907828 decreases viability and induces cell death at picomolar concentrations, in both MDM2 amplified and normal copy number, TP53 wild-type BTSC lines.
BI-907828 (50mg/kg p.o.) treatment resulted in strong activation of p53 target genes p21 and MIC1 in orthotopic tumor-bearing SCID mice.
| M.Wt | 591.46 | |
| Formula | C31H25Cl2FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xiaoguang Hao, et al. Neuro Oncol. 2022 Dec 15;noac271.
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