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Chemical Structure : BI 1467335
Catalog No.: PC-61473Not For Human Use, Lab Use Only.
BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.
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BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.
Steatohepatitis
Phase 2 Clinical
| M.Wt | 316.8 | |
| Formula | C15H21FN2O2.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schilter HC, et al. Respir Res. 2015 Mar 20;16:42.
2. Jarnicki AG, et al. Br J Pharmacol. 2016 Nov;173(22):3161-3175.
3. Katagiri D, et al. Respir Res. 2015 Mar 20;16:42.
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