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Chemical Structure : BI605906
CAS No.: 960293-88-3
Catalog No.: PC-43329Not For Human Use, Lab Use Only.
BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.
BI605906 inhibits TNF-α-dependent IκB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1β, and CXCL1/2 in vivo.
BI605906 partially inhibits the IL-1-stimulated activation of IKKε/TBK1.
| M.Wt | 432.5084 | |
| Formula | C17H22F2N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]- |
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1. Clark K, et al. Biochem J. 2011 Feb 15;434(1):93-104.
2. Cameron AR, et al. Circ Res. 2016 Aug 19;119(5):652-65.
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