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Chemical Structure : CH-223191
CAS No.: 301326-22-7
Catalog No.: PC-43148Not For Human Use, Lab Use Only.
CH-223191 is a potent, specific antagonist of AhR (aryl hydrocarbon receptor), potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $65 | In stock | |
| 25 mg | $175 | In stock | |
| 100 mg | $425 | In stock | |
| 250 mg | $695 | In stock |
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CH-223191 is a potent, specific antagonist of AhR (aryl hydrocarbon receptor), potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM; shows more inhibitory potency and no agonist-like effect, compared with flavone, resveratrol, and α-naphthoflavone, as well as estrogenic potency; inhibits TCDD-AhR binding and TCDD-induced nuclear translocation and DNA binding of AhR, prevents the expression of cytochrome P450 enzymes, target genes of the AhR; potently prevents TCDD-elicited cytochrome P450 induction, liver toxicity, and wasting syndrome in mice
| M.Wt | 333.3871 | |
| Formula | C19H19N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazole-5-carboxamide, 1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]- |
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1. Kim SH, et al. Mol Pharmacol. 2006 Jun;69(6):1871-8.
2. Veldhoen M, et al. J Exp Med. 2009 Jan 16;206(1):43-9.
3. Gramatzki D, et al. Oncogene. 2009 Jul 16;28(28):2593-605.
4. Shackleford G, et al. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1319-E1328.
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