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Chemical Structure : CK-2127107
Catalog No.: PC-60222Not For Human Use, Lab Use Only.
CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
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CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats.
Spinal Muscular Atrophy (SMA)
Phase 2 Clinical
| M.Wt | 384.391 | |
| Formula | C19H18F2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68.
2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.
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