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Chemical Structure : CKD-516
Catalog No.: PC-35472Not For Human Use, Lab Use Only.
CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo.
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CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo; demonstrates potent cytotoxicity against several cancer cells including P-gp overexpressing MDR positive cell line (HCT15), also induces cell cycle arrest at G(2)/M phase, which is associated with strong inhibition of tubulin polymerization; shows antitumor efficacy against both murine tumors (CT26 and 3LL) and human xenogratfs (HCT116 and HCT15) in mice.
Colon Cancer
Phase 2 Clinical
| M.Wt | 536.607 | |
| Formula | C26H28N6O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee J, et al. J Med Chem. 2010 Sep 9;53(17):6337-54.
2. Kim KW, et al. Invest New Drugs. 2013 Oct;31(5):1097-106.
3. Lee J, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6327-30.
4. Kim YI, et al. Anticancer Res. 2014 Apr;34(4):1715-22.
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