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Chemical Structure : Ceapin A7
CAS No.: 2323027-38-7
Catalog No.: PC-73217Not For Human Use, Lab Use Only.
Ceapin A7 is a selective inhibitor of ATF6α with IC50 of 0.59 uM, selective over ATF6β, PERK and other branches of the unfolded protein response (UPR).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 100 mg | $958 | In stock | |
| 200 mg | $1580 | In stock | |
| 1 g | Get quote |
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Ceapin A7 is a selective inhibitor of ATF6α with IC50 of 0.59 uM, selective over ATF6β, PERK and other branches of the unfolded protein response (UPR).
Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro.
Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.
Ceapin-A7 could phenocopy the results obtained using genetic ablation of ATF6α in mouse models.
Ceapin-A7 is a first-in-class series of ATF6α inhibitors that selectively blocks ATF6α and not ATF6β, SREBP or other UPR branches.
| M.Wt | 470.33 | |
| Formula | C20H12F6N4O3 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Ciara M Gallagher, et al. eLife. 2016; 5: e11878.
2. Mufrrih M, et al. mSphere. 2021 Jun 30;6(3):e0036121.
3. Ma M, et al. iScience. 2021 Jun 28;24(7):102791.
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