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Chemical Structure : EGA
Catalog No.: PC-70343Not For Human Use, Lab Use Only.
A potent anthrax lethal toxin entry inhibitor with IC50 of 1.7 uM, inhibits endosomal trafficking pathways exploited by multiple toxins and viruses.
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A potent anthrax lethal toxin entry inhibitor with IC50 of 1.7 uM, inhibits endosomal trafficking pathways exploited by multiple toxins and viruses; also delays lysosomal targeting and degradation of the EGF receptor, does not neutralize acidic organelles; a powerful tool for the study of membrane trafficking and represents a class of host-targeted compounds for therapeutic development to treat infectious disease.
| M.Wt | 346.22 | |
| Formula | C16H16BrN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gillespie EJ, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12.
2. Jung ME, et al. ACS Med Chem Lett. 2014 Jan 21;5(4):363-7.
3. Slater LH, et al. Trends Microbiol. 2014 Feb;22(2):53-5.
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