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Chemical Structure : EML-633
Catalog No.: PC-70164Not For Human Use, Lab Use Only.
EML-633 (EML633) small-molecule inhibitor of methyllysine reader protein SPIN1 (Spindlin 1) with Kd of 2 uM.
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EML-633 (EML633) small-molecule inhibitor of methyllysine reader protein SPIN1 (Spindlin 1) with Kd of 2 uM.
EML-633 shows increased selectivity and engages SPIN1 in cells, block its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity.
| M.Wt | 682.998 | |
| Formula | C42H62N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bae N, et al. Nat Chem Biol. 2017 May 15. doi: 10.1038/nchembio.2377.
2. Wang W, et al. EMBO Rep. 2011 Oct 28;12(11):1160-6.
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