Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ENPP1 inhibitor QS1
Catalog No.: PC-72235Not For Human Use, Lab Use Only.
ENPP1 inhibitor QS1 (QPS1) is a potent, selective non-competitive inhibitor of Ectonucleotide pyrophosphatase/PDE1 (NPP1, ENPP1) with Ki of 59.3 nM.
QPS1 also significantly inhibited the K121Q NPP1 gene variant with Ki of 59.2 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ENPP1 inhibitor QS1 (QPS1) is a potent, selective non-competitive inhibitor of Ectonucleotide pyrophosphatase/PDE1 (NPP1, ENPP1) with Ki of 59.3 nM.
QPS1 also significantly inhibited the K121Q NPP1 gene variant with Ki of 59.2 nM.
ENPP1 inhibitor QS1 (QPS1) did not significantly alter the activity of other nucleotide metabolizing ectoenzymes expressed at the cell surface, namely NPP3, NTPDases (1–3), ecto-5′-nucleotidase and ALP.
ENPP1 inhibitor QS1 (QPS1) (10 uM) prevented phosphate-induced mineralization of VICs and lowered the rise of osteogenic genes as expected for NPP1 inhibition.
In ENPP1 null cells, QS1 also increased intracellular cGAMP and decreased extracellular cGAMP concentrations, suggesting that it blocks the cGAMP exporter.
ENPP1 inhibitor QS1 (QPS1) inhibits extracellular cGAMP degradation in cells overexpressing ENPP1.
| M.Wt | 395.478 | |
| Formula | C17H25N5O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
|
|
1. Elnur Elyar Shayhidin, et al. Br J Pharmacol. 2015 Aug;172(16):4189-99.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
