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Chemical Structure : GGTI 2418
CAS No.: 501010-06-6
Catalog No.: PC-62152Not For Human Use, Lab Use Only.
GGTI 2418 (GGTI-2418, PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | $898 | In stock | |
| 100 mg | $898 | In stock | |
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| 1 g | Get quote |
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GGTI 2418 (GGTI-2418, PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
GGTI 2418 demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM.
GGTI 2418 suppresses the growth of human breast tumors in nude mouse xenografts.
GGTI 2418 increases p27(Kip1) and induces significant regression of breast tumors.
| M.Wt | 441.532 | |
| Formula | C23H31N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-((S)-2-benzyl-4-((4-methyl-1H-imidazol-5-yl)methyl)-3-oxopiperazine-1-carboxamido)-4-methylpentanoic acid |
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1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558.
2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63.
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