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Chemical Structure : GGTI 2418 sodium
Catalog No.: PC-62153Not For Human Use, Lab Use Only.
GGTI 2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
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GGTI 2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase; demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM; suppresses the growth of human breast tumors in nude mouse xenografts; increases p27(Kip1) and induces significant regression of breast tumors.
| M.Wt | 463.514 | |
| Formula | C23H30N5NaO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558.
2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63.
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