Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GPR52 antagonist Comp-43
CAS No.: 1239987-91-7
Catalog No.: PC-72128Not For Human Use, Lab Use Only.
GPR52 antagonist Comp-43 is a highly potent and specific GPR52 antagonist with IC50 of 0.63 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $178 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GPR52 antagonist Comp-43 is a highly potent and specific GPR52 antagonist with IC50 of 0.63 uM.
Comp-43 showed no effects on the cAMP elevation or calcium response stimulated by other GPCRs (β2AR, GCGR, GLP-1R, CCR5, α-1D adrenergic receptor, and dopamine D2 receptor (DRD2).
Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons.
Comp-43 not only reduces mHTT levels but also rescues Huntington's disease (HD)-related phenotypes in HdhQ140 mice.
| M.Wt | 242.336 | |
| Formula | C15H14OS | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO (2.4 mg/mL) |
|
| Chemical Name/SMILES |
(2E)-5-phenyl-1-(2-thienyl)-2-penten-1-one |
|
1. Hidetoshi Komatsu. J Med Chem. 2021 Jan 28;64(2):938-940.
2. Congcong Wang, et al. J Med Chem. 2021 Jan 28;64(2):941-957.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
