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Chemical Structure : GS-9451
Catalog No.: PC-63007Not For Human Use, Lab Use Only.
GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.
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GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays; exhibits low toxicity and high selectivity over mammalian proteases.
HCV Infection
Phase 2 Discontinued
| M.Wt | 910.525 | |
| Formula | C45H60ClN7O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sheng XC, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2629-34.
2. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5289-95.
3. Yang H, et al. Antimicrob Agents Chemother. 2014;58(2):647-53.
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