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Chemical Structure : GSK-2256098
CAS No.: 1224887-10-8
Catalog No.: PC-42177Not For Human Use, Lab Use Only.
GSK-2256098 (GTPL-7939) is a potent, selective, reversible and ATP-competitive inhibitor of FAK kinase with Ki of 0.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $80 | In stock | |
| 10 mg | $120 | In stock | |
| 25 mg | $240 | In stock | |
| 50 mg | $432 | In stock | |
| 100 mg | Get quote |
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GSK-2256098 (GTPL-7939) is a potent, selective, reversible and ATP-competitive inhibitor of FAK kinase with Ki of 0.4 nM; dispalys high selectivity over a panel of 261 kinases, including the nearest FAK family member, Pyk2 (>1,000-fold); inhibits FAK activity through targeting the phosphorylation site of FAK Y397; decreases levels of phosphorylated Akt and ERK, cell viability, anchorage-independent growth, and motility in L3.6P1 cells; causes lower microvessel density, less cellular proliferation, and higher apoptosis rates in the Ishikawa model.
Pancreatic Cancer
Phase 2 Clinical
| M.Wt | 414.8886 | |
| Formula | C20H23ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy- |
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1. Zhang J, et al. Cell Cycle. 2014;13(19):3143-9.
2. Soria JC, et al. Ann Oncol. 2016 Dec;27(12):2268-2274.
3. Thanapprapasr D, et al. Mol Cancer Ther. 2015 Jun;14(6):1466-1475.
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