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Chemical Structure : GSK-983
Catalog No.: PC-72538Not For Human Use, Lab Use Only.
GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM.
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GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM.
GSK983 inhibits the growth of cell lines immortalized by HTLV-1, EBV, HPV, SV40 and Ad-5, with EC50 values in the range of 10-40 nM.
GSK983 induces either apoptosis or cytostasis at concentrations over 20 nM.
GSK983 also inhibits cell lines immortalized by non-viral mechanisms, but has little effect on primary cells.
GSK983 inhibited K562 cell growth with an IC50 of 21 nM, GSK983 treatment caused an accumulation of K562 cells in S phase.
GSK983 inhibits DHODH to block virus replication and cell proliferation.
GSK983 displayed a marked inhibitory effect on the proliferation of neuroblastoma cell lines with IC50 values from nanomoles to low micromoles.
| M.Wt | 325.796 | |
| Formula | C18H16ClN3O | |
| Appearance | Solid | |
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1. Qi Liu, et al. Cell Chem Biol. 2020 Jun 18;27(6):668-677.e9.
2. Robert Harvey, et al. Antiviral Res. 2009 Apr;82(1):1-11.
3. Yajie Yu, et al. Cell Death Dis. 2021 Aug 30;12(9):821.
4. Richard M Deans, et al. Nat Chem Biol. 2016 May;12(5):361-6.
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