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Chemical Structure : GW-4869
CAS No.: 6823-69-4
Catalog No.: PC-45623Not For Human Use, Lab Use Only.
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 25 mg | $278 | In stock | |
| 100 mg | Get quote |
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GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM; does not inhibit acid SMase (>150 uM); partially inhibits TNF-induced sphingomyelin (SM) hydrolysis at 10 uM.
| M.Wt | 577.5 | |
| Formula | C30H28N6O2 · 2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 0.044 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) |
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1. Luberto C, et al. J Biol Chem. 2002 Oct 25;277(43):41128-39.
2. Marchesini N, et al. J Biol Chem. 2003 Apr 18;278(16):13775-83.
3. Airola MV, et al. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5549-E5558.
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