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Chemical Structure : HJC-0338
Catalog No.: PC-63110Not For Human Use, Lab Use Only.
HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.
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HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2; exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM; selectively block cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation.
| M.Wt | 280.192 | |
| Formula | C15H15Cl2N | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62.
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