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Chemical Structure : HJC-0350
Catalog No.: PC-44643Not For Human Use, Lab Use Only.
A potent and specific EPAC2 antagonist with IC50 of 0.3 uM for competing with 8-NBD-cAMP in binding EPAC2, about 133-fold more potent than cAMP.
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A potent and specific EPAC2 antagonist with IC50 of 0.3 uM for competing with 8-NBD-cAMP in binding EPAC2, about 133-fold more potent than cAMP; exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM; selectively blocks cAMP-induced EPAC2 activation but does not inhibit cAMP-mediated PKA activation, fully blocks the 007-AM induced decrease of FRET in HEK293/EPAC2-FL cells at 10 uM.
| M.Wt | 277.38 | |
| Formula | C15H19NO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62.
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