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Chemical Structure : IM156
CAS No.: 1422365-93-2
Catalog No.: PC-49735Not For Human Use, Lab Use Only.
IM156 (HL156A) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 25 mg | $398 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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IM156 (HL156A) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin.
HL156A, combined with TMZ, inhibited the stemness of GMB tumorspheres.
Combined treatment with HL156A and TMZ showed survival benefits in an orthotopic xenograft mouse model.
IM156 (HL156A) prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways.
IM156 (HL156A) suppressed AT84 mouse oral tumor growth, accompanied by down-regulated p-IGF-1, p-mTOR, proliferating cell nuclear antigen (PCNA) and promoted p-AMPK and TUNEL expression.
| M.Wt | 315.30 | |
| Formula | C13H16F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(N-(4-(trifluoromethoxy)phenyl)carbamimidoyl)pyrrolidine-1-carboximidamide |
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1. Izreig S, et al. Cell Rep Med. 2020 May 19;1(2):100014.
2. Willette RN, et al. J Pharmacol Exp Ther. 2021 Nov;379(3):290-300.
3. Choi J, et al. Oncotarget. 2016;7:65643–65659.
4. Lam TG, et al. Cancer Sci. 2018;109:699–709.
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