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Chemical Structure : JNJ-18038683
CAS No.: 851376-05-1
Catalog No.: PC-63400Not For Human Use, Lab Use Only.
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 25 mg | $498 | In stock | |
| 100 mg | $1280 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays.
JNJ-18038683 decreases 5-HT (100 nM)-stimulated adenylyl cyclase in rat and human 5-HT7/HEK293 cells with pKb of 8.01 and 7.99, respectively.
JNJ-18038683 shows 10-fold selectivity over h5-HT6 receptor, 15-fold selectivity over rat adrenergic α1 receptor, 14- to 25-fold selectivity over the h5-HT2 receptor subtypes, and 20-fold selectivity over h5-HT1B receptor.
JNJ-18038683 prolongs rapid eye movement (REM) sleep and decreases REM duration induced by citalopram in vivo.
| M.Wt | 529.974 | |
| Formula | C26H28ClN3O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydro-1-(phenylmethyl)pyrazolo[3,4-d]azepine 2-hydroxy-1,2,3-propanetricarboxylate |
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1. Bonaventure P, et al. J Pharmacol Exp Ther. 2012 Aug;342(2):429-40.
2. Shelton J, et al. Front Behav Neurosci. 2015 Jan 15;8:453.
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