Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JNJ 39220675
Catalog No.: PC-61661Not For Human Use, Lab Use Only.
JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3; dose-dependently reduces both alcohol intake and preference in alcohol-preferring rats, reduces alcohol self-administration without changing saccharin self-administration in alcohol non-dependent rats.
Other Indication
Phase 2 Discontinued
| M.Wt | 369.44 | |
| Formula | C21H24FN3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Letavic MA, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4.
2. Galici R, et al. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
3. Nuutinen S, et al. Neuropharmacology. 2016 Jul;106:156-63.
4. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
