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Chemical Structure : K-858
CAS No.: 72926-24-0
Catalog No.: PC-45767Not For Human Use, Lab Use Only.
A potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $96 | In stock | |
| 50 mg | $360 | In stock | |
| 100 mg | $520 | In stock |
Bulk size, bulk discount!
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A potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM; displays >150-fold more selective for Eg5 than other members of the kinesin superfamily; induces mitotic arrest, apoptosis, and cell growth inhibition through the activation of the Mad2-mediated spindle checkpoint, and has no effect on microtubule polymerization; exhibits potent antitumor activity in xenograft models of cancer, and induces the accumulation of mitotic cells with monopolar spindles in tumor tissues.
Breast Cancer
Preclinical
| M.Wt | 277.3421 | |
| Formula | C13H15N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)- |
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1. Nakai R, et al. Cancer Res. 2009 May 1;69(9):3901-9.
2. De Iuliis F, et al. Invest New Drugs. 2016 Aug;34(4):399-406.
3. De Monte C, et al. Eur J Med Chem. 2015 Nov 13;105:245-62.
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