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Chemical Structure : KSQ4279
Catalog No.: PC-73318Not For Human Use, Lab Use Only.
KSQ4279 (KSQ-4279) is a potent, selective, first-in-class inhibitor of USP1, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2.
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KSQ4279 (KSQ-4279) is a potent, selective, first-in-class inhibitor of USP1 with Ki of 1.2 nM, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2.
KSQ-4279 has a unique mode of allosteric binding to USP1 and a high degree of selectivity over other family members.
USP1 is a protein regulating DNA damage response (DDR).
KSQ-4279 demonstrated efficacy both as a single agent and in combination with PARP inhibitors across multiple BRCA/HRD xenograft model.
| M.Wt | 534.547 | |
| Formula | C27H25F3N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sol Shenker, et al. Cancer Res (2021) 81 (13_Supplement): 1337.
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