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Chemical Structure : LOXO-195
CAS No.: 2097002-61-2
Catalog No.: PC-60901Not For Human Use, Lab Use Only.
LOXO-195 (Selitrectinib;LOXO 195, LOXO195) is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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LOXO-195 (Selitrectinib;LOXO 195, LOXO195) is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively;.
LOXO-195 also diplays high potentcy against mutant TrkA G595R, TrkA G667C, TrkC G623R and TrkC G696A with IC50 of 2.0, 9.8, 2.3 and <2.5 nM, respectively.
LOXO-195 overcomes acquired resistance mediated by recurrent kinase domain (solvent front and xDFG) mutations identified in multiple patients.
| M.Wt | 380.427 | |
| Formula | C20H21FN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(13E,14E,22R,6R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one |
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1. Drilon A, et al. Cancer Discov. 2017 Sep;7(9):963-972.
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