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Chemical Structure : LY-345899
CAS No.: 10538-99-5
Catalog No.: PC-70211Not For Human Use, Lab Use Only.
LY-345899 (LY345899) is a novel potent, cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with IC50 of 96 nM and 663 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 25 mg | $798 | In stock | |
| 100 mg | $1880 | In stock | |
| 1 g | Get quote | ||
| 5 g | Get quote |
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LY-345899 (LY345899) is a novel potent, cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with IC50 of 96 nM and 663 nM, respectively; MTHFD2 is a novel target for drug development.
| M.Wt | 471.43 | |
| Formula | C20H21N7O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-(3-amino-1-hydroxy-9-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl)-L-glutamic acid |
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1. Tedeschi PM, et al. Mol Cancer Res. 2015 Oct;13(10):1361-6.
2. Gustafsson R, et al. Cancer Res. 2017 Feb 15;77(4):937-948.
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