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Chemical Structure : MK-4074 sodium salt
Catalog No.: PC-61206Not For Human Use, Lab Use Only.
MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM.
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MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver.
Steatohepatitis
Phase 1 Clinical
| M.Wt | 587.608 | |
| Formula | C33H30N3NaO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6.
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