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Chemical Structure : NCGC00185684
Catalog No.: PC-61554Not For Human Use, Lab Use Only.
NCGC00185684 (ML154) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor.
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NCGC00185684 (ML154) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor;GPR154) antagonist with IC50 of 22.1 nM and 36.5 nM in Ca2+ assay and cAMP assay, respectively; shows biased antagonist properties, and preferentially blocks ERK-phosphorylation over intracellular cAMP or calcium responses to NPS in vitro; blocks alcohol-induced ERK-phosphorylation in the rat central amygdala, also decreases operant alcohol self-administration, and lowers motivation for alcohol reward in rats.
| M.Wt | 545.47 | |
| Formula | C29H26N2PS.Br | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Thorsell A, et al. J Neurosci. 2013 Jun 12;33(24):10132-42.
2. Patnaik S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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