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Chemical Structure : NH-125
Catalog No.: PC-70179Not For Human Use, Lab Use Only.
A potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells.
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A potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells; shows relative selectivity over other protein kinases: PKC (IC50=7.5 uM), PKA (IC(50=80 uM), and CaMKII (IC50>100 uM); shows efficacious anti-proliferation activityt against different cancer cells.
| M.Wt | 524.56 | |
| Formula | C27H45IN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamamoto K, et al. Biosci Biotechnol Biochem. 2000 Apr;64(4):919-23.
2. Arora S, et al. Cancer Res. 2003 Oct 15;63(20):6894-9.
3. Chen Z, et al. J Biol Chem. 2011 Dec 23;286(51):43951-8.
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