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Chemical Structure : OX-14
Catalog No.: PC-61730Not For Human Use, Lab Use Only.
OX-14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite.
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OX-14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite; inhibits bone resorption, significantly prevents the formation of osteolytic lesions in JJN3-NSG murine model of myeloma-induced bone disease; a new, highly potent bisphosphonate with lower bone binding affinity than other clinically relevant bisphosphonates.
| M.Wt | 324.141 | |
| Formula | C9H11FN2O6P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lawson MA, et al. J Bone Miner Res. 2017 Sep;32(9):1860-1869.
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