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Chemical Structure : PAT-1251
CAS No.: 2007885-39-2
Catalog No.: PC-61128Not For Human Use, Lab Use Only.
Lenumlostat (GB2064, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $298 | In stock | |
| 5 mg | $488 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Lenumlostat (GB2064, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases.
PAT1251 exhibits efficacy in mouse bleomycin lung fibrosis model.
| M.Wt | 399.346 | |
| Formula | C18H17F4N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone |
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1. Rowbottom MW, et al. J Med Chem. 2017 May 25;60(10):4403-4423.
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