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Chemical Structure : PF-05175157
CAS No.: 1301214-47-0
Catalog No.: PC-63466Not For Human Use, Lab Use Only.
PF-05175157 (PF-5175157) is a potennt Acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 27 and 33 nM for hAAC1 and hACC2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 100 mg | $658 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PF-05175157 (PF-5175157) is a potennt Acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 27 and 33 nM for hAAC1 and hACC2, respectively.
PF-05175157 shows concentration-dependent reductions in both skeletal muscle and liver malonyl-CoA with EC50 of 870 and 540 nM after 1 h following an acute oral dose in rats.
PF-05175157 demonstrates significant potential for the treatment of type 2 diabetes mellitus (T2DM).
| M.Wt | 405.49 | |
| Formula | C23H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)spiro[5H-indazole-5,4'-piperidin]-7(6H)-one |
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1. Griffith DA, et al. J Med Chem. 2014 Dec 26;57(24):10512-26.
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