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Chemical Structure : PK-11007
Catalog No.: PC-61495Not For Human Use, Lab Use Only.
A 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells.
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A 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells; stabilizes p53 in vitro via selective alkylation of two surface-exposed cysteines without compromising p53 DNA binding activity; also induces cell death independent of p53, but with highly elevated levels of ROS and induction of ER stress.
| M.Wt | 236.63 | |
| Formula | C6H5ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bauer MR, et al. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5271-80.
2. Duffy MJ, et al. Eur J Cancer. 2017 Sep;83:258-265.
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