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Chemical Structure : PK-7088
CAS No.: 1446352-67-5
Catalog No.: PC-62081Not For Human Use, Lab Use Only.
PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria..
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PK-7088 (PK7088) is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.
| M.Wt | 223.279 | |
| Formula | C14H13N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazole |
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1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44.
2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61.
3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.
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