Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PVZB-1194
Catalog No.: PC-62339Not For Human Use, Lab Use Only.
PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.
| M.Wt | 319.274 | |
| Formula | C13H9F4NO2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61.
2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
