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Chemical Structure : Phortress
CAS No.: 328087-38-3
Catalog No.: PC-60777Not For Human Use, Lab Use Only.
Phortress (NSC710305) is the L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
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Phortress (NSC710305) is the L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
Phortress (NSC710305) causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells.
Phortress (NSC710305) induces CYP1A1 and CYP1B1 transcription; demonstrats antitumor activity in vivo.
| M.Wt | 459.405 | |
| Formula | C20H25Cl2FN4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide dihydrochloride |
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1. Bradshaw TD, et al. Mol Cancer Ther. 2002 Feb;1(4):239-46.
2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
3. Trapani V, et al. Br J Cancer. 2003 Feb 24;88(4):599-605.
4. Leong CO, et al. Br J Cancer. 2003 Feb 10;88(3):470-7.
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