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Chemical Structure : Pim inhibitor 28
Catalog No.: PC-35980Not For Human Use, Lab Use Only.
Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors.
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Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors.
| M.Wt | 403.486 | |
| Formula | C23H25N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang HL, et al. J Med Chem. 2019 Jan 9. doi: 10.1021/acs.jmedchem.8b01733.
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