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Chemical Structure : Pyrotinib
CAS No.: 1269662-73-8
Catalog No.: PC-70084Not For Human Use, Lab Use Only.
Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively.
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Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively.
Pyrotinib (SHR-1258) displays high selectivity in a panel of different kinases such as KDR, c-Kit, PDGFRβ, c-Src and c-Met (c-Src with an IC50 of 790 nM, and others >3,000 nM).
Pyrotinib (SHR-1258) exhibits robust anti-tumor effects on HER2-overexpressing xenograft models and sufficiently safety windows in animals as well as favorable pharmacokinetic properties in human.
| M.Wt | 583.089 | |
| Formula | C32H31ClN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide |
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1. Li X, et al. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X.
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