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Chemical Structure : RS 102221
Catalog No.: PC-60815Not For Human Use, Lab Use Only.
A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.
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A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively; demonstrates 100-fold selectivity for the 5-HT2C versus 5-HT2A and 5-HT2B receptors; acts as an antagonist in a cell-based microphysiometry functional assay with pA2 of 8.1 and has no detectable intrinsic efficacy; increases food-intake and weight-gain in rats (2 mg/kg, i.p.); reverses the inhibitory effects of MK-212 and DOI on 'monosynaptic and 'intermediate' neurones.
| M.Wt | 649.08 | |
| Formula | C27H31F3N4O7S.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bonhaus DW, et al. Neuropharmacology. 1997 Apr-May;36(4-5):621-9.
2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15;861:269.
3. Sévoz-Couche C, et al. Br J Pharmacol. 2000 Dec;131(7):1445-53.
4. McMahon LR, et al. J Neurosci. 2001 Oct 1;21(19):7781-7.
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