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Chemical Structure : SAR-405838
CAS No.: 1303607-60-4
Catalog No.: PC-45588Not For Human Use, Lab Use Only.
SAR-405838(MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 50 mg | $648 | In stock | |
| 100 mg | $1040 | In stock |
Bulk size, bulk discount!
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SAR-405838(MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM; activates wild-type p53 in vitro and causes p53-dependent cell-cycle arrest and/or apoptosis; shows durable tumor regression or complete tumor growth inhibition in mouse xenograft models of SJSA-1 osteosarcoma, RS4;11 acute leukemia, LNCaP prostate cancer, and HCT-116 colon cancer; orally bioactive.
Blood Cancer
Phase 1 Clinical
| M.Wt | 562.503 | |
| Formula | C29H34Cl2FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2'S,3R,4'S,5'R)- |
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1. Wang S, et al. Cancer Res. 2014 Oct 15;74(20):5855-65.
2. Bill KL, et al. Clin Cancer Res. 2016 Mar 1;22(5):1150-60.
3. Lu J, et al. Oncotarget. 2016 Dec 13;7(50):82757-82769.
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