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Chemical Structure : SB 206553
Catalog No.: PC-62760Not For Human Use, Lab Use Only.
SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes.
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SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes; exhibits anxiolytic-like properties both in vitro and in vivo.
Anxiety
Discontinued
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Forbes IT, et al. J Med Chem. 1995 Jul 7;38(14):2524-30.
2. Upton N, et al. Eur J Pharmacol. 1998 Oct 16;359(1):33-40.
3. Kennett GA, et al. Br J Pharmacol. 1996 Feb;117(3):427-434.
4. Porras G, et al. Neuropsychopharmacology. 2002 Mar;26(3):311-24.
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