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Chemical Structure : SGI-1776
CAS No.: 1025065-69-3
Catalog No.: PC-43464Not For Human Use, Lab Use Only.
SGI-1776 is a potent, selective, orally active Pim kinase inhibitor with IC50 of 7, 363 and 69 nM for Pim1, Pim2 and Pim3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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SGI-1776 is a potent, selective, orally active Pim kinase inhibitor with IC50 of 7, 363 and 69 nM for Pim1, Pim2 and Pim3, respectively.
SGI-1776 exhibits promising selectivity against a panel of >300 kinases, shows inhibitory activity against two other kinases: Flt-3 (IC50=44 nM) and Haspin (IC50=34 nM);.
SGI-1776 reduces cell viability of androgen-independent prostate cancer cell lines with IC50 of 2-4 uM, causes cell cycle arrest and caspase-dependent apoptosis in prostate cancer cells, marginally sensitizes prostate cancer cells to taxane-based therapeutics by inhibiting MDR1 activity and inducing apoptosis.
SGI-1776 shows efficacy in xenograft model bearing MV-4-11 tumors.
| M.Wt | 405.42 | |
| Formula | C20H22F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]- |
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1. Chen LS, et al. Blood. 2009 Nov 5;114(19):4150-7.
2. Chen LS, et al. Blood. 2011 Jul 21;118(3):693-702.
3. Chang M, et al. Mol Cancer Ther. 2010 Sep;9(9):2478-87.
4. Mumenthaler SM, et al. Mol Cancer Ther. 2009 Oct;8(10):2882-93.
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