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Chemical Structure : SHMT inhibitor SHIN2
Catalog No.: PC-72579Not For Human Use, Lab Use Only.
SHMT inhibitor SHIN2 ((+) SHIN2) is a potent, selective, mammalian SHMT1/2 inhibitor with antileukemic effect in vivo.
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SHMT inhibitor SHIN2 ((+) SHIN2) is a potent, selective, mammalian SHMT1/2 inhibitor with antileukemic effect in vivo.
(+) SHIN2 blocked proliferation of HCT116 Ras-driven colon cancer cells with IC50 of 300 nM.
(+)SHIN2 inhibited proliferation across various human T-ALL cell lines, and was particularly potent against the human T-ALL cell line Molt4 (IC50=90 nM), a prototypical T-ALL cell line harboring activating mutations in NOTCH1.
(+) SHIN2 (200 mg/kg BID, IP) showed therapeutic activity in mouse primary T-ALL in vivo, significantly decreased tumor burden soon after treatment initiation;
(+)SHIN2 demonstrated synergistic in vivo antileukemic effect with DHFR inhibitor Methotrexate in mouse primary leukemia in Molt3 and Jurkat human T-ALL cell lines, and in human patient-derived T-ALL xenograft.
| M.Wt | 406.486 | |
| Formula | C23H26N4O3 | |
| Appearance | Solid | |
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1. García-Cañaveras JC, et al. Leukemia. 2021 Feb;35(2):377-388.
2. Zhaoyue Zhang, et al. Nat Metab. 2021 Dec;3(12):1608-1620.
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