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Chemical Structure : SLC-0111
CAS No.: 178606-66-1
Catalog No.: PC-70028Not For Human Use, Lab Use Only.
SLC-0111 is a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor with IC50 of 45 nM and 4.5 nM for tumor-associated enzymes hCA IX and hCA XII.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $128 | In stock | |
| 100 mg | $228 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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SLC-0111 (U-104) is a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor with IC50 of 45 nM and 4.5 nM for tumor-associated enzymes hCA IX and hCA XII.
SLC-0111 (U-104) showed selective CA IX/XII inhibitory profiles, displays >20-fold and >100-fold selectivity over hCA II and hCA I, respectively.
SLC-0111 (U-104) reduces tumor cell growth and increases apoptotic cell death in prostate cancer cells.
| M.Wt | 309.315 | |
| Formula | C13H12FN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(3-(4-fluorophenyl)ureido)benzenesulfonamide |
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1. Pacchiano F, et al. J Med Chem. 2011 Mar 24;54(6):1896-902.
2. Congiu C, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3850-3.
3. Riemann A, et al. Oncol Res. 2017 Jun 19. doi: 10.3727/096504017X14965111926391.
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