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Chemical Structure : SLMP53‐1
Catalog No.: PC-61497Not For Human Use, Lab Use Only.
A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
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A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity.
| M.Wt | 318.376 | |
| Formula | C20H18N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soares J, et al. Oncotarget. 2016 Jan 26;7(4):4326-43.
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