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Chemical Structure : SMARCA-PB1 inhibitor 22
Catalog No.: PC-73226Not For Human Use, Lab Use Only.
SMARCA-PB1 inhibitor 22 is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.
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SMARCA-PB1 inhibitor 22 is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.
SMARCA-PB1 inhibitor 22 displays little to no affinity for PB1(2) PB1(3) and PB1(4) (IC50=1.9->10 uM).
SMARCA-PB1 inhibitor 22 blocked adipocyte differentiation at 1.0 μM in 3T3-L1 murine fibroblasts.
SMARCA-PB1 inhibitor 22 blocks the expression of key genes during adipogenesis, including the transcription factors PPARγ and C/EBPα, and impaired the differentiation of 3T3-L1 murine fibroblasts into adipocytes.
| M.Wt | 371.441 | |
| Formula | C19H25N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marek Wanior, et al. J Med Chem. 2020 Dec 10;63(23):14680-14699.
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