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Chemical Structure : STO-609
CAS No.: 52029-86-4
Catalog No.: PC-45723Not For Human Use, Lab Use Only.
STO-609 is a selective and cell-permeable inhibitor of CaM-KK, inhibits recombinant CaM-KKα and CaM-KKβ with Ki of 80 and 15 ng/ml.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $318 | In stock | |
| 100 mg | $528 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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STO-609 is a selective and cell-permeable inhibitor of CaM-KK, inhibits recombinant CaM-KKα and CaM-KKβ with Ki of 80 and 15 ng/ml.
STO-609 shows no any significant effect on the downstream CaM kinases (CaM-KI and -IV, IC50 >10 ug).
STO-609 suppresses the Ca(2+)-induced activation of CaM-KIV in a dose-dependent manner in transfected HeLa cells.
STO-609 significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (1 ug/ml, 80% inhibition).
| M.Wt | 314.2943 | |
| Formula | C19H10N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 5.6 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo- |
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1. Tokumitsu H, et al. J Biol Chem. 2002 May 3;277(18):15813-8.
2. Fujiwara Y, et al. Biochemistry. 2015 Jun 30;54(25):3969-77.
3. Lin F, et al. Hepatology. 2015 Aug;62(2):505-20.
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