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Chemical Structure : TG-101209
CAS No.: 936091-14-4
Catalog No.: PC-42570Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable JAK2 inhibitor with IC50 of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 50 mg | $324 | In stock | |
| 100 mg | $600 | In stock |
Bulk size, bulk discount!
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A potent, selective, orally bioavailable JAK2 inhibitor with IC50 of 6 nM; also inhibits FLT3 (IC50=25 nM) and RET (IC50=17 nM) kinases, weakly inhibits JAK3 (IC50=168 nM); inhibits growth of Ba/F3 cells expressing JAK2V617F or MPLW515L mutations with IC50 of 200 nM, induces cell cycle arrest and apoptosis, and inhibits phosphorylation of JAK2V617F, STAT5 and STAT3; attenuates myelofibrosis in murine model of JAK2V617F-induced polycythemia vera; also potently inhibits BRD4 with Kd of 123 nM.
Bone Cancer
Preclinical
| M.Wt | 509.6668 | |
| Formula | C26H35N7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenesulfonamide, N-(1,1-dimethylethyl)-3-[[5-methyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]- |
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1. Pardanani A, et al. Leukemia. 2007 Aug;21(8):1658-68.
2. Libani IV, et al. Blood. 2008 Aug 1;112(3):875-85.
3. Ciceri P, et al. Nat Chem Biol. 2014 Apr;10(4):305-12.
4. Wang Y, et al. Blood. 2009 Dec 3;114(24):5024-33.
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