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Chemical Structure : Tenovin-1
CAS No.: 380315-80-0
Catalog No.: PC-43528Not For Human Use, Lab Use Only.
Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $136 | In stock | |
| 100 mg | $248 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2; causes significantly greater growth inhibition, cell death via apoptosis, as well as superior p53 promoter upregulation in wtp53 MyLa cells when combined with vorinostat; elicits caspase-mediated cell death in p53 wild-type cells, but caspase-independent cell death in p53 null cells.
| M.Wt | 369.4805 | |
| Formula | C20H23N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)- |
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1. Lain S, et al. Cancer Cell. 2008 May;13(5):454-63.
2. Sonnemann J, et al. Br J Cancer. 2014 Feb 4;110(3):656-67.
3. Nihal M, et al. Cell Cycle. 2014;13(4):632-40. doi: 10.4161/cc.27523.
4. Marx C, et al. Invest New Drugs. 2018 Jun;36(3):396-406.
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