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Chemical Structure : UBE2M-DCN1 inhibitor 52
Catalog No.: PC-63291Not For Human Use, Lab Use Only.
UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM.
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UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM.
UBE2M-DCN1 inhibitor 52 binds to DCN1 and selectively reduce steady-state levels of neddylated CUL1 and CUL3 in a squamous cell carcinoma cell line.
UBE2M-DCN1 inhibitor 52 inhibits DCN1 but not DCN3 stimulated NEDD8 transfer from UBE2F to the cullins.
| M.Wt | 447.546 | |
| Formula | C25H32F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hammill JT, et al. J Med Chem. 2018 Apr 12;61(7):2680-2693.
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